Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2
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چکیده
منابع مشابه
Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells.
Dimethylated histone H3 lysine 9 (H3K9me2) is a critical epigenetic mark for gene repression and silencing and plays an essential role in embryogenesis and carcinogenesis. Here, we investigated the effects of hypoxic stress on H3K9me2 at both global and gene-specific level. We found that hypoxia increased global H3K9me2 in several mammalian cell lines. This hypoxia-induced H3K9me2 was temporall...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2009
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb.1569